Role of elastin for maintenance of young and healthy skin
Elastic fibres is an essential part of human skin. They are required to maintain elastic function of the skin over lifetime. Loss of elasticity, as a result of elastic fibre degradation, is a major contributing factor in ageing of connective tissues, including skin.
The production of elastin in the body decreases significantly over lifetime, and by the time we are middle-aged, only a trickle of elastin is produced. Thus we rely mostly on the elastin that was deposited in the womb and during the first years of life.
However, in the event of damage to the elastin in the skin of adults following sun burns or simply as a result of ageing, the low level of elastin production may mean that the damage cannot be efficiently repaired, and the skin gradually loses its elasticity.
Oral and topical application of Elastin
For many years oral and topical application of Elastin has been pursued by researches as useful in the regeneration of elastic tissues.
Oral administration of Elastin found its place in anti-aging supplements for skin suffering from dryness, environmental stresses, or irritation. The recommended daily dosage of oral Elastin is 200 mg.
Topical application of Elastin is based on elastin’s ability to bind to moisture. Elastin can hold up to 1,000 times its weight in water, making it an excellent natural skin plumper.
Our Elastin grade contains min 1 % of Desmosine + Isodesmosine. BIOFAC can manufacture Elastin grades tailored to the customers’ specifications. In particular, we offer Elastin isolated from porcine aorta and Elastin originated from fish.
The manufacturing process includes a solvent-free extraction method with further purification steps such as ultra-filtration, and spray drying.
Storage and Stability
The product should be stored in original and tightly closed containers at room temperature, not exceeding 25 °C. The product is a hygroscopic powder that easily absorbs humidity from the air. Expiry date is 2 years from date of production, if stored as advised above.
Elastin: main characteristics and role in skin ageing
Elastin with an approximate molecular mass of 64-66 kDa, is a key extracellular matrix (ECM) protein, critical to the recoil capacity of human tissues, including skin. It constitutes around 2-5% of the skin’s dry weight and helps to return skin to its original state. The biology of skin ageing is a complex process and has the end effect of reducing the production of extracellular matrix proteins. Clearly, one of the most pronounced effects of ageing is the degradation of the elastic fibres network.
Effect of Elastin peptides on skin elasticity, repair and regeneration
Medical illustration of the effects of osteoporosis in the course of a woman’s life.
- Danish Environmental Protection Agency (Danish EPA) has made a categorization of BIOFAC as to an instruction No. 6 of 2004 on Differential Environmental Review and assessed that BIOFAC is placed in Category 1 (the best category) because of the high level of systematism and high level of regulatory compliance.
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