Advantages of BIOFAC Hem Iron
Hem Iron is more easily absorbed by human body, compared to inorganic iron. This is due to the fact that Hem iron’s intake is not influenced by the many ligands in the diet; furthermore, it is directly taken up into enterocytes by an absorption pathway different from that of inorganic iron. Hem iron is also unaffected by the high pH of the upper small bowel, which renders some forms of inorganic iron insoluble.
No risk of iron overtake
Interestingly, uptake of Hem Iron by the transporter is regulated by the iron level in the body. While inorganic iron is transported to the body through nonselective iron channels, Hem iron has its own heme transporter, meaning no other metal ions can interfere with Hem iron absorption. As Hem iron channel is regulated, it is no risk of the overloading, while intake of inorganic needs to be cautiously controlled.
Iron overload can cause serious health risk because of the generation of reactive oxygen species by free iron.
(Schayeghi M, et. Al. Identification of an intestinal heme transporter. 2005. Cell 122,789-801
Balla G., et al. Iron loading of endothelial cells augments oxidant damage. J. Lab. Clin. Med. 11+,546-554)
Solubility of iron products is an important factor, because the solubility directly affects absorption efficacy in the body. BIOFAC has developed a Soluble Hem Iron grade, soluble at a wide range of pH.
BIOFAC Hem Iron: a few if any gastrointestinal side effects
Women and kids who are the major users of iron supplements often suffer of inorganic iron supplements gastrointestinal side effects., such as nausea and constipation. The Iron complex in Hem-Iron has major advantages as an oral iron source, since the product is gentle to the digestive system. Unlike inorganic iron, Hem Iron normally leaves the user with very little or no digestive disturbances.
Storage and stability
BIOFAC Hem Iron is a hygroscopic product that easily absorbs humidity from the air. It should be stored at room temperature not exceeding 25•C in tight containers. The re-test date for BIOFAC Hem Iron is 2 years from the date of production.
BIOFAC Hem Iron: description and origin
Dietary iron is categorized into non-hem / inorganic iron and hem iron / organic based on the source of the iron.
BIOFAC Hem Iron extracted from the red blood corpuscles of blood, the product contains an organic bound iron, the ferriprotoporphyrin. It is a black crystalline or amorphous powder with a faint characteristic smell.
Importance of the efficient iron supplements for women.
Efficient iron supplement is in particular important for women in their reproductive years.
A man with 4 g of body store will lose only 1 mg per day, whereas women during the reproductive years will lose approximately twice that amount because of menstruation and childbirth.
Finch C.A., et al .Body iron loss in animals. Proc. Soc. Exp. Biol. Med. 1978, 159,335-338
Conrad M.E., et. al. Iron absorption and transport. Am. J. Med. Sci. 1999 318, 213-229.
BIOFAC Hem Iron: a few if any gastrointestinal side effects.
- BIOFAC Hem Iron is manufactured at our GMP – certified factory by Danish Health and Medicines Authorities.
- Danish Environmental Protection Agency (Danish EPA) has made a categorization of BIOFAC as to an instruction No. 6 of 2004 on Differential Environmental Review and assessed that BIOFAC is placed in Category 1 (the best category) because of the high level of systematism and high level of regulatory compliance.
- Danish Working Environment Authority has given BIOFAC a green Smiley, indicating that BIOFAC has no issues with the Working Environment Authority, providing a high level of health and safety.