Elastin For skin health
BIOFAC’s Elastin, with its naturally occuring content of desmosine and isodesmosine, helps to regenerate elastic tissues, restoring the skin’s natural resilience and youth.
REVITALIZE YOUR SKIN’S ELASTICITY
Elastin is a vital protein essential for maintaining skin’s elasticity and firmness, acting as a key marker of overall skin health (1). Aging, genetics, UV exposure, and pollution reduce Elastin production, and due to its slow and rare natural replenishment, it’s crucial to protect and restore Elastin (1; 2). BIOFAC’s Elastin, with its naturally occuring content of desmosine and isodesmosine, helps to regenerate elastic tissues, restoring the skin’s natural resilience and youth.
BIOFAC’S ELASTIN
By taking advantages of our 75 years of expertise in the pharmaceutical and nutraceutical industries,
BIOFAC produces the highest quality Elastin on the market, as it comprises:
- Up to 1,8 % of Desmosine and Isodesmosine, enabling elastic properties of elastin.
- Produced from aorta through a lenient manufacturing process without any use of chemicals.
- Tailored production for both oral and topical use.
- Production takes place at our GMP certified factory located in Denmark, guaranteeing highest quality and safety standards.
- Our flexible production line allows us to produce according to customer specifications.
FIG. 1: Aging of Elastic Fibers
Elastin is an extracellular matrix (ECM) protein, responsible for the extensibility and elastic recoil of tissues and skin (1; 6). Fibroblasts produce elastin from tropoelastin, which is then cross-linked with microfibrils by lysyl oxidase, forming Desmosine and Isodesmosine, that are crucial for the structural integrity of elastic fibers (2;3).
Elastogenesis, the process of elastin formation, is highly active during fetal stage and decreases with age increase (1;6).
Elastin synthesis is reactivated only during injury, and Elastin and its derivatives significantly affect wound healing stages through its influence on cell growth, migration, proliferation, differentiation, and modulation of the coagulation cascade (6), thereby reducing wound contraction and improving regeneration of the dermis (1; 5;6;7).
As we age, elastic fibers are subjected to various enzymatic, chemical, and physical stresses, leading to impaired function and reduced tissue elasticity. These changes can contribute to the onset and progression of several severe pathologies (9).
ELASTIN, THE ELASTIC BACKBONE, IS VITAL THROUGHOUT LIFE
The skin’s inability to naturally repair elastic fibers has led to therapies focused on protecting elastin fibers rather than replacing them (1). During aging, elastic fibers are exposed to a variety of enzymatic, chemical, and biophysical influences, which may results in impaired elastic fiber function, reduced tissue elasticity, and all these effect may contribute to the development and progression of several severe pathologies(9), see Fig. 1. Both oral and topical applications of (porcine) elastin have therefore been explored (1). In vivo studies have shown that oral elastin supplements (200 mg/day) significantly enhanced skin elasticity measured via cutometer after 16 wks (4). Additionally, an oral intake of elastin has been linked to hydration, elasticity, transepidermal water loss (TEWL), and reduction in wrinkles (1;8).
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Regulatory Compliance
- GMP certified factory by the strictest Danish Medicines Agency.
- All biological raw materials utilized at the factory have been veterinary controlled and fulfil EU requirements. Danish Environmental Agency (Danish EPA) has classified BIOFAC as Cat. 1 (best category), because of the high level of systematism and regulatory compliance.
- Danish Working Environment Authority has assigned BIOFAC with a green Smiley, indicating the BIOFAC has no issues with the Working Environment Authority, providing a high level and safety.
