Hydrolyzed Chicken Collagen Type II


Around 650 million individuals globally are diagnosed with joint health issues, cause of disability, and impaired quality of life (1,2). As we age, our natural production of collagen declines, which impacts our ability to lubricate our joints and absorb physical impact. Type II collagen is the most abundant collagen found in cartilage and joints comprising up to 90 % of the total collagen content, thereby making it a potent nutrient for supporting joint health and maintaining an active lifestyle (2,3).


By taking advantages of our 75 years of expertise in the pharmaceutical and nutraceutical industries, BIOFAC produces the highest quality Hydrolyzed Chicken Collagen Type II on the market, as it comprises:


BIOFAC offers the following Chicken Collagen Type II products:

Hydrolyzed Chicken Collagen Type II

  • Chicken Collagen Type II, 10 % CS: Extracted from Chicken sternum, comprising high amounts of Chondroitin Sulphate (CS), Hyaluronic Acid, and Hydroxyproline. Further customized variants, e.g., with 20 % CS, are possible
  • Chicken Collagen Type II, 90 %: Extracted from Chicken sternum, comprising 90 % proteins (Type II Collagens). Chondroitin and Hyaluronic amounts are present, but not measured through analysis.

Undenatured Chicken Collagen Type II

  • Native Chicken Collagen Type II: Extracted from Chicken sternum through our own, developed in-house production process resulting in a premium Chicken Collagen Type II.


Hydrolyzed Chicken Collagen Type II is thought to aid in cartilage regeneration by providing material for the synthesis of collagen in situ. In particular, oral administration of collagen-derived bioactive oligopeptides, specifically hydroxyproline, are major contributing factors to the beneficial effects on osteoarthritis and osteoporosis (7) Studies on hydroxyproline have shown effectiveness on osteoblast differentiation and thereby joint health in recent years.(7,8)

Fig. A.
Overview of average hydroxyproline content in BIOFAC Hydrolyzed Chicken Collagen Type II vs. main market products

Osteoarthritis is the most common joint disease resulting from a complex sequence of wear and tear destructions of the cartilage and is most often linked to the combined effects of ageing, obesity, strenuous exercise, and heavy work activities (2, 8, 9).
Several clinical studies have shown that oral administration of Chicken Collagen Type II hydrolysates can improve the symptoms of osteoarthritis, such as joint stiffness and pain (4, 5).
In particular, administration of hydrolyzed Chicken Collagen Type II led to a significant reduction in pain in hip, knee, and shoulders resulting from intense physical activity as compared to placebo group.
Prophylactic treatment with Chicken Collagen Type II has also been linked to improved joint health (8, 9)


BIOFAC’s Hydrolyzed Chicken Collagens Type II should be stored in original and tightly closed containers at room temperature (not exceeding 25 °C). Retest date is 2 years from date of production, if stored as advised. All products are primarily packed in food approved-, light- and airtight aluminum bags followed by fiber drums.

Regulatory Compliance

  • GMP certified under the strictest quality and environmental regulations. 

  • Food Approval by Ministry of Environment and Food of Denmark, Danish Veterinary and Food Administration.

  • All biological raw materials utilized at the factory have been veterinary controlled and fulfil EU requirements. Danish
    Environmental Protection Agency (Danish EPA) has made a categorization of BIOFAC as to an instruction No. 6 of 2004
    on Differential Environmental Review and assessed that BIOFAC is classified as Category 1 (the best category) because
    of the high level of systematism and high level of regulatory compliance.

  • Danish Working Environment Authority has assigned BIOFAC with a green Smiley, indicating that BIOFAC
    has no issues with the Working Environment Authority, providing a high level of health and safety.

Sources: 1) Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies. Cui et al. (2020). Clinical Medicine 29-30. 2) Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders: a review of literature. Bello et al. (2006). Current Medical Research and Opinion Vol.22; 11; 2221-32. 3) Collagen type II: From biosynthesis to advanced biomaterials for cartilage engineering. Biomaterials and Biosystems. (2021), Vol. 21. 4) Efficacy of a Hydrolyzed Chicken Collagen Type II in Alleviating Joint Discomfort (ON GOING FDA). 5) A multicenter, double-blind, randomized, controlled phase III clinical trial of chicken type II collagen in rheumatoid arthritis. Wei Wei et al. (2009). Arthritis Research & Therapy, 11: 180. 6) A randomized, double-blind, multicenter, controlled clinical trial of chicken type II collagen in patients with rheumatoid arthritis. Ling-Ling et al. (2008), Arthritis Rheumatology, 15;59 (7):905-10. 7) Identification of a highly stable bioactive 3-hydroxyprolinecontaining tripeptide in human blood after collagen hydrolysate ingestion. Yuki Taga et al. (2022), Science of Food 6:29. 8) A Double-Blind, Randomized, Placebo-Controlled Trial to Evaluate the Efficacy of a Hydrolyzed Chicken Collagen Type II Supplement in Alleviating Joint Discomfort. Mohammed & He (2021). Nutrients, 13, 2454. 9) Role of Collagen Hydrolysate in Bone and Joint Disease. Moskowitz, (2000). Seminars in Arthritis and Rheumatism, Vol 30; 2; p.87-99.

By continuing to browse the site, you accept our use of cookies