Intrinsic Factor

BIOFAC Intrinsic Factor is produced from porcine gastric mucosa.

UNLOCK THE KEY TO B12 ABSORPTION – WITH BIOFAC’S INTRINSIC FACTOR

Vitamin B12 deficiency is a widespread issue, especially in older adults and those with gastrointestinal conditions or surgery. A primary cause is the absence or insuffiency of Intrinsic Factor (IF) – a glycoprotein essential for the absorption of vitamin B12 (1; 2). Without Intrinsic Factor, even adequate dietary intake of vitamin B12 cannot prevent deficiency, leading to megaloblastic anemia, neurological impairments, and increased morbidity (3-5). BIOFAC INTRINSIC FACTOR ensures effective vitamin B12 aborption, ideal for pharmaceutical, diagnostic, and nutritional applications targeting B12 deficiency.

BIOFAC’S INTRINSIC FACTOR

By taking advantages of our 75 years of expertise in the pharmaceutical and nutraceutical industries, BIOFAC produces the highest quality IF on the market.

Our IF is a clinically active, lyophilized protein powder developed for among others:

Funtional foods and clinical nutrition.
Support and prevention of mild to moderate B12 deficiency.
Diagnostic use (e.g. Schilling Test, Vitamin B12 binding assays).

INTRINSIC FACTOR

IF is a glycoprotein secreted by gastric parietal cells, essential for the active absorption of vitamin B12 (cobalamin) in the terminal ileum. Without IF, B12 cannot be absorbed efficiently and is instead excreted in the stool (3-6). Reduced IF production-commonly seen in atrophic gastritis or impaired receptor binding in the intestine – can cause clinically significant B12 deficiency. Vitamin B12 is released from food in the stomach by gastric acid and pepsin, then binds to Intrinsic Factor in the duodenum. The B12–IF complex is absorbed in the terminal ileum via specific receptors. Without IF, absorption is impaired.

Regulatory Compliance

Manufactured at GMP plant under the strictest quality and environmental regulations.
Danish Environmental Protection Agency (Danish EPA) has made a categorization of BIOFAC as to an instruction No. 6 of 2004 on Differential Environmental Review and assessed that BIOFAC is classified as Category 1 (the best category) because of the high level of systematism and high level of regulatory compliance.
Danish Working Environment Authority has assigned BIOFAC with a green Smiley, indicating that BIOFAC has no issues with the Working Environment Authority, providing a high level of health and safety.