Thyroid USP (GMP)
Mechanism of action
The thyroid gland plays a major role in the metabolism and development of the human body. It constantly produces and releases thyroid hormones into the bloodstream, Liothyronine (T3) and Levothyroxine (T4) being the major players. These hormones are essential for normal development, growth, neural differentiation and metabolic regulation (Brent, 2012).
They function by increasing the basal metabolic rate (BMR) and needed to stay warm, have strong heartbeat and in general increasing the energy usage of the body.
BIOFAC manufactures Thyroid Powder from porcine thyroid gland according to USP with standardized content of both T3 and T4 hormones.
The oral products with Thyroid Powder is a well-known option for patients with hypothyroidism.
Advantages of Thyroid Powder compared to synthetic T4
Storage and Stability
BIOFAC Thyroid Powder is a hygroscopic product that easily absorbs humidity from the air. It should be stored in original and tightly closed containers at room temperature not exceeding 25 C. The re- test date is 2 years from the date of production if stored as advised above.
The thyroid gland is located in the front lower part of the neck. Hormones released by the gland travel through a bloodstream and affect nearly every part of the body, from heart and brain, to muscles and skin.
T4 is the primary isoform of thyroid hormone produced in the thyroid gland whereas the active form, T3, is produced to a lesser extent. In target tissues deiodinases are responsible for the conversion of T4 to T3, a process necessary due to T3’s higher affinity for thyroid hormone receptors (Aranda, A., Alonso-Merino, E. and Zambrano, A. (2013) ‘Receptors of thyroid hormones.’, Pediatric endocrinology reviews : PER).
Hypothyroidism: Causes and symptoms
Raw material safety standards
The raw material for BIOFAC Thyroid Powder are porcine thyroids from animals controlled by an official veterinarian and found fit for human consumption
- GMP certificate by Danish Medicines Agency
- All biological raw materials utilized at the factory have been veterinary controlled and fulfil EU requirements.
- Danish Environmental Protection Agency (Danish EPA) has made a categorization of BIOFAC as to an instruction
No. 6 of 2004 on Differential Environmental Review and assessed that BIOFAC is classified as Category 1 (the best
category) because of the high level of systematism and high level of regulatory compliance.
- Danish Working Environment Authority has assigned BIOFAC with a green Smiley, indicating that BIOFAC has no
issues with the Working Environment Authority, providing a high level of health and safety.