Placenta Extract (GMP)
BIOFAC offers premium Placenta Extracts for skin health, wound healing, and wellness – trusted across pharmaceutical, nutraceutical, and cosmetic applications.
PLACENTA EXTRACTS - FOR WOUND HEALING
BIOFAC PE Liquid is a GMP and Halal-certified product. BIOFAC also supplies GMP-certified bovine PE in powder grade.
ACCELERATING RECOVERY:
THE THERAPEUTIC POWER OF PLACENTA EXTRACTS
Our skin acts as the main barrier and plays vital roles in immunity, thermoregulation, and fluid homeostasis (1; 2). Due to natural aging, genetics, UV rays, and environmental pollution, our skin undertakes several degenerative processes, resulting in moisture loss and wrinkle formation (1).
Placenta extract (PE) has a long history of traditional use for skin rejuvenation and revitalization (1).
PE has demonstrated potential in accelerating wound healing, reducing inflammation, and promoting tissue repair (1, 2; 3)
BIOFAC’S PLACENTA EXTRACT
By taking advantages of our 75 years of expertise in the pharmaceutical and nutraceutical industries, BIOFAC produces the highest quality Placenta Extract on the market, as it comprises:
- Manufactured from premium bovine raw material sourced from selected, certified partner-farms known for excellent animal welfare standards.
- Special lenient manufacturing process allows to preserve product wholeness and highest bioactivity.
- Product is GMP certified, guaranteeing highest quality and safety standards
- Our flexible production line allows us to produce according to customer specifications.
PLACENTA EXTRACT PROMOTES WOUND HEALING PROCESSES
PE, rich in growth factors, cytokines, and bioactive compounds, enhances wound healing (1; 2; 3). Recent studies highlight its benefits for chronic and non-healing wounds when used topically (2). PE has been linked to several mechanisms involved in wound healing processes, which are higlighted below in Fig. 1.
1. Hemostasis (Blood clotting)
Although most research focuses on PE beyond this stage of wound healing, it could be considered that the components within PE, such as growth factors, could theoretically support the clotting processes by activating local cells to stabilize the wound initially.
2. Inflammation (Immune defense activation)
PE significantly reduces inflammation and oxidative stress when applied topically in in vitro models, suggesting its potential to modulate inflammatory responses, that is vital for creating an environment conducive to effective wound healing, hereby preventing prolonged inflammation, tissue damage and delayed wound repair (3; 9).
3. Proliferation (Growth of new tissue and vessels)
PE promotes the proliferation of cells involved in wound healing, expectedly due to its content of growth factors, suggesting a potential contribution to accelerated wound closure (3; 7; 8) . Studies also indicate that PE significantly reduces ROS overproduction in high glucose conditions, enhancing endothelial cell viability, migration, and angiogenesis crucial for wound healing (5).
4. Remodeling (Strengthening and refinement of new tissue)
PE reduces the expression of genes (e.g. MMPS) involved in both collagen synthesis and degradation, while also preventing a decrease in tissue inhibitors’ expression (e.g. TIMPs). This leads to enhanced collagen synthesis and reduced collagen degradation, crucial for the structural integrity and strength of healed tissue (7; 8) .
5. Immune Modulation
Although there are few studies, PE demonstrates immunomodulatory and antioxidant effects, potentially reducing the risk of infection in wounds and supporting the healing process (4; 6).
The effect of PE on wound healing
WOUND HEALING
1. Hemostasis (Blood clotting)
2. Inflammation (Immune defense activation)
3. Proliferation (Growth of new tissue and vessels)
4. Remodeling (Strengthening and refinement of new tissue)
5. Immune Modulation
The effect of BIOFAC Placenta Extract on wound healing may relate to its effect on cell proliferation, inflammation, collagen synthesis and degradation, angiogenetic effect, and to immunologic effect described above, resulting from the natural content of bioactive and anti-inflammatory components in PE, such as proteins, lipids, hormones, cytokines, growth factors, glycosaminoglycan, nucleic acids,vitamins, and minerals (1; 6) .
Storage and Stability
BIOFAC PE Liquid should be stored in original and tightly closed containers at 15-30 °C. Retest date is 3 years from date of production if stored as advised above.
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Regulatory Compliance
- GMP certified by the strictest Danish quality and medicine agency.
All biological raw materials utilized at the factory have been veterinary controlled and fulfil EU requirements. Danish
Environmental Protection Agency (Danish EPA) has made a categorization of BIOFAC as to an instruction No. 6 of 2004
on Differential Environmental Review and assessed that BIOFAC is classified as Category 1 (the best category) because
of the high level of systematism and high level of regulatory compliance.Danish Working Environment Authority has assigned BIOFAC with a green Smiley, indicating that BIOFAC
has no issues with the Working Environment Authority, providing a high level of health and safety.
Sources: 1) Protzman, N. et al. (2023): Placental-Derived Biomaterials and Their Application to Wound Healing: A Review. Bioengineering, 10; 829. 2) Nagae, M., et al. (2020): Effect of Porcine Placenta Extract Supplement on Skin Condition in Healthy Adult Women: A Randomized, Double-Blind Placebo-Controlled Study. Nutrients, 12(6), 1671. 3) Wu et al. (2003): Wound healing effects of porcine placenta extracts on rats with thermal injury. Br. J. Dermatology; 148: 236-45. 4) Choi H.Y. et al. (2014): Alpha-fetoprotein, identified as a novel marker for the antioxidant effect of placental extract, exhibits synergistic antioxidant activity in the presence of estradiol. PLoS One, 12;9, 6. 5) Nensat, C. et al. (2021): Porcine placenta extract improves high-glucose-induced angiogenesis impairment. BMC Complementary Medicine and Therapies, 66. 6) Lee, K.H., et al. (2013): Immune modulation effect of porcine placenta extracts in weaned pig. Journ. of Animal Science, 91(5), 2405-13. 7) Mizutani, Y. et al. (2009): Ceramide biosynthesis in keratinocyte and its role in skin function. Biochimie Vol. 91, 6, P.784-90. 8) Yoshikawa, C. et al. (2013): Effect of Porcine Placental Extract on Collagen Production in Human Skin Fibroblasts in vitro. Gynecol. Obstet., Vol. 3, 6. 9) Heo, J.H. et al. (2018): Topical anti-inflammatory and anti-oxidative effects of porcine placenta extracts on 2,4-dinitrochlorobenzene-induced contact dermatitis. BMC Complementary Medicine and Therapies.