Placenta Extract for skin health
BIOFAC offers premium Placenta Extracts for skin health, wound healing, and wellness – trusted across pharmaceutical, nutraceutical, and cosmetic applications.
PLACENTA EXTRACTS - FOR skin health
BIOFAC PE can be produced from sheep, horse, porcine, and halal-certified bovine raw materials, each offering unique health and cosmetic benefits.
DELIVERING SKIN HEALTH AND BEAUTY SINCE ANCIENT TIMES
Our skin acts as the main barrier and plays several vital roles in immunity, thermoregulation, and fluid homeostasis (1; 2). Due to natural aging, genetics, UV rays, and environmental pollution, our skin undertakes several degenerative processes, resulting in moisture loss and wrinkle formation. Since ancient times, Placenta extract (PE) has traditionally been used for skin rejuvenation and vitalization (1). Oral intake of PE is associated with enhancement of skin hydration and improvement in the appearance of wrinkles, which is directly linked to maintaining a healthy skin (1, 2; 3).
BIOFAC’S PLACENTA EXTRACT
By taking advantages of our 75 years of expertise in the pharmaceutical and nutraceutical industries, BIOFAC produces the highest quality Placenta Extract on the market, as it comprises:
- Manufactured from premium raw materials sourced from select certified partner-farms known for excellent animal welfare standards.
- Special lenient manufacturing process allows to preserve wholeness of the product and highest content of its bioactive components
- Production takes place at our GMP certified factory located in Denmark, guaranteeing highest quality and safety standards.
- Our flexible production line allows us to produce according to customer specifications.
ORAL INTAKE OF PLACENTA EXTRACT PROMOTES SKIN REGENERATION
Research shows that PE significantly enhances skin hydration, which is vital for maintaining barrier function and reducing wrinkle development (1; 2), see Fig. 1.
PE and skin hydration
In vivo studies revealed that mice given oral PE for 12 weeks had a higher trans-epidermal water loss (TEWL) value (5; 6). In humans, oral PE intake of 200 mg/day led to significant improvements in skin hydration and reductions in TEWL at 4, 8, and 12 weeks compared to baseline and placebo values (2).
PE and wrinkle reduction
Oral intake of PE (200 mg/day) significantly reduces wrinkle formation at 12 weeks; both total wrinkle area and wrinkle area % values significantly decreased compared to baseline in healthy adults (1). PE also inhibits genes involved in collagen degradation (e.g., MMP-2, MMP-9) and promotes expression of tissue inhibitors (TIMP-1, TIMP-2), enhancing collagen synthesis and reducing its breakdown, essential for tissue strength (1; 6). Additionally, PE influences fibroblast activity and ceramide synthase expression levels, related to collagen synthesis (4; 5).
The effect of BIOFAC PE on skin hydration and wrinkle reduction
The effect of BIOFAC Placenta Extract on skin hydration and wrinkle reduction may relate to collagen synthesis and degradation, as well as to the content of bioactive and anti-inflammatory components in PE, such as proteins, lipids, hormones, cytokines, growth factors, glycosaminoglycan, nucleic acids, vitamins, and minerals (1; 6). Additionally, PE also promotes several wound healing processes (7). , which may also be linked to its effect on skin health.
- Increased expression level of ceramide synthase in epidermis
- Fibroblast generation and differentiation in dermis involved in collagen expression
- Lowering of MMP-2 and MMP-9 mrna involved in degradation of collagen
Storage and Stability
BIOFAC Placenta should be stored in original and tightly closed containers at room temperature (not exceeding 25°C). Placenta Extract powder grade is a very hygroscopic product that easily absorbs humidity from the air. Retest date is 2 years from date of production if stored as advised above.
Products Navigation
Regulatory Compliance
- GMP certified by the strictest Danish quality and medicine agency.
All biological raw materials utilized at the factory have been veterinary controlled and fulfil EU requirements. Danish
Environmental Protection Agency (Danish EPA) has made a categorization of BIOFAC as to an instruction No. 6 of 2004
on Differential Environmental Review and assessed that BIOFAC is classified as Category 1 (the best category) because
of the high level of systematism and high level of regulatory compliance.Danish Working Environment Authority has assigned BIOFAC with a green Smiley, indicating that BIOFAC
has no issues with the Working Environment Authority, providing a high level of health and safety.
Sources: 1) Jung, E. Y. & Y. H. Hong (2022): Oral Intake of porcine placental extract improves skin hydration and wrinkles in a double-blind placebo-controlled clinical study. Progress in Nutri. Col. 25, N.1. 2) vNagae, M. et al. (2022): Effects of oral administration of equine placental extract supplement on the facial skin of healthy adult women: A randomized, double-blind, placebo-controlled study. Health Science Reports, Vol. 5, 2, 3) Lewis, M. R. et al. (2012): Review: Placenta, evolution and lifelong health. Elsevier, Vol.33, p S28-S32. 4) Mizutani, Y. et al. (2009): Ceramide biosynthesis in keratinocyte and its role in skin function. Biochimie Vol. 91, 6, P.784-90. 5) Yoshikawa, C. et al. (2013): Effect of Porcine Placental Extract on Collagen Production in Human Skin Fibroblasts in vitro. Gynecol. Obstet., Vol. 3, 6. 6) Hong. K-B. (2015): Effects of Porcine Placenta Extract Ingestion on Ultraviolet B-induced Skin Damage in Hairless Mice. Korean J. Food Sci. An. Vol. 35, 3, pp. 413-20. 7) Protzman, N. et al. (2023): Placental-Derived Biomaterials And Their Application To Wound Healing: A Review. Bioengineering, 10;829.