Placenta Extract Luxury
BIOFAC offers a premium grade Placenta Extract for luxury cosmetics, with full traceability from high-quality porcine raw materials sourced exclusively from certified Danish partner farms known for exceptional animal welfare standards.
DISCOVER THE SECRET TO LUXURIOUS HEALTHY SKIN
Our skin acts as the main barrier and plays several vital roles in immunity, thermoregulation, and fluid homeostasis (1; 2). Due to natural aging, genetics, UV rays, and environmental pollution, our skin undertakes several degenerative processes, resulting in moisture loss and wrinkle formation. Since ancient times,Placenta extract (PE) has traditionally been used for skin rejuvenation and vitalization (1), . Oral PE intake is linked to enhanced skin hydration and improved wrinkles, directly associated to healthy skin (1, 2; 3).
BIOFAC’S LUXURY PLACENTA COSMETIC
By taking advantages of our 75 years of expertise in the pharmaceutical and nutraceutical industries, BIOFAC produces the highest quality luxurious Placenta Cosmetic on the market, as it comprises:
- Full traceability from luxurios and premium raw materials of porcine origin sourced from select certified partner-farms in DK known for excellent animal welfare standards.
- Special lenient manufacturing process allows to preserve wholeness of the product and highest content of its bioactive components designed for cosmetic excellence
- Production takes place at our GMP certified factory located in Denmark, guaranteeing highest quality and safety standards.
- Our flexible production line allows us to produce according to customer specifications
ORAL INTAKE OF PLACENTA EXTRACT PROMOTES SKIN REGENERATION
Research shows that PE significantly enhances skin hydration, which is vital for maintaining barrier function and reducing wrinkle development (1; 2), see Fig. 1.
PE and skin hydration
In vivo studies revealed that mice given oral PE for 12 weeks had a higher trans-epidermal water loss (TEWL) value (5; 6). In humans, oral PE intake of 200 mg/day led to significant improvements in skin hydration and reductions in TEWL at 4, 8, and 12 weeks compared to baseline and placebo values (2).
PE and wrinkle reduction
Oral intake of PE (200 mg/day) significantly reduces wrinkle formation at 12 weeks; both total wrinkle area and wrinkle area % values significantly decreased compared to baseline in healthy adults (1). PE also inhibits genes involved in collagen degradation (e.g., MMP-2, MMP-9) and promotes expression of tissue inhibitors (TIMP-1, TIMP-2), enhancing collagen synthesis and reducing its breakdown, essential for tissue strength (1; 6). Additionally, PE influences fibroblast activity and ceramide synthase expression levels, related to collagen synthesis (4; 5).
The effect of oral PE and skin hydration and wrinkle reduction
The effect of BIOFAC Placenta Cosmetic on skin hydration and wrinkle reduction may relate to collagen synthesis and degradation, as well as to the content of bioactive and anti-inflammatory components in PE, such as proteins, lipids, hormones, cytokines, growth factors, glycosaminoglycan, nucleic acids, vitamins, and minerals (1;6). Additionally, PE also promotes several wound healing processes (7), which may also be linked to its effect on skin health.
- Increased expression level of ceramide synthase in epidermis
- Fibroblast generation and differentiation in dermis involved in collagen expression
- Lowering of MMP-2 and MMP-9 mrna involved in degradation of collagen
Storage and Stability
Placenta should be stored in original and tightly closed containers at room temperature (not exceeding 25°C). Placenta Extract powder grade is a very hygroscopic product that easily absorbs humidity from the air. Retest date is 2 years from date of production if stored as advised above.
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Regulatory Compliance
- GMP certified by the strictest Danish quality and medicine agency.
All biological raw materials utilized at the factory have been veterinary controlled and fulfil EU requirements. Danish
Environmental Protection Agency (Danish EPA) has made a categorization of BIOFAC as to an instruction No. 6 of 2004
on Differential Environmental Review and assessed that BIOFAC is classified as Category 1 (the best category) because
of the high level of systematism and high level of regulatory compliance.Danish Working Environment Authority has assigned BIOFAC with a green Smiley, indicating that BIOFAC
has no issues with the Working Environment Authority, providing a high level of health and safety.
Sources: 1) Protzman, N. et al. (2023): Placental-Derived Biomaterials and Their Application to Wound Healing: A Review. Bioengineering, 10; 829. 2) Nagae, M., et al. (2020): Effect of Porcine Placenta Extract Supplement on Skin Condition in Healthy Adult Women: A Randomized, Double-Blind Placebo-Controlled Study. Nutrients, 12(6), 1671. 3) Wu et al. (2003): Wound healing effects of porcine placenta extracts on rats with thermal injury. Br. J. Dermatology; 148: 236-45. 4) Choi H.Y. et al. (2014): Alpha-fetoprotein, identified as a novel marker for the antioxidant effect of placental extract, exhibits synergistic antioxidant activity in the presence of estradiol. PLoS One, 12;9, 6. 5) Nensat, C. et al. (2021): Porcine placenta extract improves high-glucose-induced angiogenesis impairment. BMC Complementary Medicine and Therapies, 66. 6) Lee, K.H., et al. (2013): Immune modulation effect of porcine placenta extracts in weaned pig. Journ. of Animal Science, 91(5), 2405-13. 7) Mizutani, Y. et al. (2009): Ceramide biosynthesis in keratinocyte and its role in skin function. Biochimie Vol. 91, 6, P.784-90. 8) Yoshikawa, C. et al. (2013): Effect of Porcine Placental Extract on Collagen Production in Human Skin Fibroblasts in vitro. Gynecol. Obstet., Vol. 3, 6. 9) Heo, J.H. et al. (2018): Topical anti-inflammatory and anti-oxidative effects of porcine placenta extracts on 2,4-dinitrochlorobenzene-induced contact dermatitis. BMC Complementary Medicine and Therapies.