Native Chicken Collagen
Application in patients with Rheumatoid Arthritis and Osteoarthritis
Several studies have shown that oral intake of low doses of native chicken collagen have positive effects on symptoms such as joint swelling and joint paint in patients with RA, strongly indicating a dampening of the chronic inflammation present in these patients (Barnett, Combitchi and Trentham, 1996; Barnett et al., 1998). The mechanism of action is thought to be by oral tolerance. Oral tolerance is initiated, when an antigen, in this case native chicken collagen type II, passes through the gut and the gut-associated-lymphoid-tissue induces systemic tolerance towards that antigen through the activation of regulatory T-cells (Weiner and Wu, 2011). Additionally, a recent study indicates that the joint pain of OA can be relieved by oral intake of native chicken collagen type II (Bakilan et al., 2016).
Bakilan, F. et al. (2016) ‘Effects of Native Type II Collagen Treatment on Knee Osteoarthritis: A Randomized Controlled Trial’, The Eurasian Journal of Medicine. doi: 10.5152/eurasianjmed.2015.15030.
Barnett, M. L. et al. (1998) ‘Treatment of rheumatoid arthritis with oral type II collagen. Results of a multicenter, double-blind, placebo-controlled trial.’, Arthritis and rheumatism. doi: 10.1002/1529-0131(199802)41:2<290::AID- ART13>3.0.CO;2-R.
Barnett, M. L., Combitchi, D. and Trentham, D. E. (1996) ‘A pilot trial of oral type II collagen in the treatment of juvenile rheumatoid arthritis.’, Arthritis and rheumatism.
Weiner, H. L. and Wu, H. Y. (2011) ‘Oral tolerance.’, Immunologic research. doi: 10.1385/IR:28:3:265.
Low daily dose for effective treatment
To initiate the oral tolerance mechanism and provide effective treatment opportunity for patients with joint paint a dose of maximum 40 mg a day* is recommended.
* The value is a reference value for informational purposes. It is up to manufacturer of finished dosage form to identify a correct daily dosage for a particular formulation.
Storage and Stability
BIOFAC Native Chicken Collagen should be stored in original and tightly closed containers or bottles at room temperature (not exceeding 25 C). Retest date is 2 years from date of production, if stored as advised above.
Chemical structure of a triple helix formed by 3 collagen molecules
(Hydrogens are omitted for clarity. Coloring per atom (upper image) and per stand (lower image)).
The most prevalent type of cartilage in human body is Hyaline cartilage and is present at the joints where it forms an elastic tissue protecting the bones and reducing friction when the body is in motion.
The most abundant protein (80-90 %) in hyaline cartilage is type II collagen making it an interesting target of research in the fields of RA and OA.
Native type II collagen consists of a triple- helical structure of three interconnected (cross-linked) collagen fibers. The studies suggest that the native three-dimensional structure might play an important role in initiating a mechanism of oral tolerance resulting in positive effect for patients with RA and OA.
Rheumatoid Arthritis and Osteoarthritis
BIOFAC Native Chicken Collagen type II is a fine white to yellowish powder with standardized properties. The standard grade is a rich cocktail of min 3% undenaturated collagen type II, minimum 20 % Chondroitin Sulfate and glycosaminoglycan. Our flexible production line allows us to produce Native Chicken Collagen Type II according to customer specifications.
- Manufactured at GMP plant under the strictest quality and environmental regulations.
- Food Approval by Ministry of Environment and Food of Denmark, Danish Veterinary and Food Administration
- All biological raw materials utilized at the factory have been veterinary controlled and fulfil EU requirements.
- Danish Environmental Protection Agency (Danish EPA) has made a categorization of BIOFAC as to an instruction
No. 6 of 2004 on Differential Environmental Review and assessed that BIOFAC is classified as Category 1 (the best
category) because of the high level of systematism and high level of regulatory compliance.
- Danish Working Environment Authority has assigned BIOFAC with a green Smiley, indicating that BIOFAC has no
issues with the Working Environment Authority, providing a high level of health and safety.